Who is affected and when-
Wilson disease is present in anyone who has two copies of the ATP7B gene and is thusly a recessively inherited trait. Most people with Wilson disease have no family history of the disease. Your chances of getting Wilson's disease increase when either of your parents has it though.
About one in 40,000 people get Wilson disease and it affects men and women the same. Symptoms usually appear between the ages of 5 to 35, but new cases have been reported in people aged 2 to 72 years. It is also a lifelong illness
( http://digestive.niddk.nih.gov/ddiseases/pubs/wilson/ )

What- Wilson's disease, a genetic disorder, is the build up of copper in the liver, brain, eyes and other organs. Wilson's disease prevents the body from getting rid of excess copper that the body doesn't need. The high copper levels can cause organ damage that is life-threatening over time.( http://digestive.niddk.nih.gov/ddiseases/pubs/wilson/ )

Where and How- Wilson's disease affects the body in these places and ways.

· Liver problems. The liver is often the first site of infection since it is where copper first accumulates. This often involves abdominal pain and yellowing of the skin and eyes (jaundice). Eventually this can cause anemia and vommitting blood. The disease is often undetectable until the onset of cirrhosis. It is hard to detect before this without testing by a doctor. Once this has happened, signs of the disease may include swelling in the abdomen or legs and an enlarged spleen.
· Neurological problems. This can also be the first site of infection, and is usually the second place of infection after the liver About one in every three people with Wilson's disease have neurological symptoms. This will cause tremors, muscular spasms, difficulty walking, impaired speech, and drooling. Once again, it is difficult to diagnose until later symptoms start presenting themselves.
· Eye problems. One of the most famous examples of a symptom for Wilson's disease is the jaundicing of the white of the eye, which is caused by copper deposits. Even these are usually first discovered during an exam by a physician.
· Kidney problems. Eventually, Wilson's Disease can impair the filtering function of the kidneys, which can cause other problems such as kidney stones.
· Bone problems. As the disease progresses, it can eventually lead to Osteoporosis

jaundiced eye; typical symptom of Wilson's Disease
· ( http://mayoclinic.com/health/wilsons-disease/DS00411/DSECTION=symptoms )

Most of the symptoms of Wilson's Disease have to be confirmed by a doctor. These include:

o Liver swelling
ospleen swelling
o Accumulation of fluid in the abdomen (ascites)
o Anemia
o Low platelet count
o Low WBC count
o Higher amino acid levels
o Buildup of Uric Acid/ Carbs in urine
o Bone Softening

Treatments/ Lifestyle Changes

· Penicillamine (Cuprimine, Depen). - This medicine is prescribed by doctors to remove copper by binding to it and creating a water soluble compound that can be expelled through urine. This drug is effective but can cause side effects including skin problems, further damge to the nervous system, and birth defects.
· Trientine (Syprine). - This can be used for removing copper via binding as well. It is less harmful than Penicillamine which makes it a first line of therapy to many doctors. This is usually reccomended for patients with either liver or neurological infections.
· Zinc acetate. - This medication will prevent your body from absorbing copper in the first place. The most negative effect of this drug is that it is slower than the others. Thusly, it is recommended only for those with a less serious infection or a less progressed infection.

There are several foods high in copper that you should avoid when you have Wilson's Disease. This includes:

· Shellfish
· Liver
· Mushrooms
· Nuts
· Chocolate
· Dried fruit and legumes
· Avocados
· Bran