Table of Contents What | Symptoms | Who | How | Where | When | Exams and Tests | Treatment | Citations




Goodpastures SyndromeAlso known as Anti-GBM disease
external image antigbmlung.jpg

What

It's when auto antibodies attack the walls of capillaries in the lungs and kidney.It's a rare disease and quickly causes lung disease and kidney failure.


Symptoms

  • Blood in urine
  • Chest pain
  • Coughing up blood
  • Dark colored urine
  • Decreased amount of urine
  • Foamy urine
  • Pale skin
  • Nausea and vomiting


Who

  • Less than 1 case per 1,000,000 people
  • Mostly young, white men aged 15-35
  • Sometimes in the late 50's for men and more likely for women then
  • Rarely in children
  • Men are eight times more likely to be affected than women


How

It occurs when the body begins producing anti-glomerular basement membrane antibodies that attack the Glomerular basement membrane in the kidneys which would normally get rid of waste and extra fluid in the blood. Anti-glomerular basement membrane antibodies attack the collagen proteins in the air sacs of the lungs and the filtering units in the kidney membrane.
Normal Cell
external image Picture1_000.jpg
Cell affected by Goodpasture's Syndrome
external image Picture2gbm.jpg


Where

  • Lungs (inflammation of the capillaries in the air sacs)
  • Kidneys (inflammation/tissue damage due to leukocytes)


When

If you have any of the symptoms especially a decrease in urine output, seek medical care ASAP! The sooner the better and the less likely you are to getting damage to your lungs and kidneys!


Exams and Tests

--> Blood pressure check
--> listening to the heart (abnormal heart rates)
--> Chest x-ray
--> Anti-glomerular basement membrane test
--> Urinalysis
--> Lung and/or kidney biopsy


Treatment

  • Strong anti-inflammatory and cytotoxic medicines
  • Plasmapheresis (remove blood and replace it with donated healthy plasma)
  • Dialysis of the kidney
  • Kidney transplant


Citations

  1. "MedlinePlus Medical Encyclopedia: Goodpasture syndrome." National Library of Medicine - National Institutes of Health. 14 May 2009 <http://www.nlm.nih.gov/medlineplus/ency/article/000142.htm>.
  2. UNC Kidney Center. 14 May 2009 <http://www.unckidneycenter.org/kidneyhealthlibrary/antigbm.html>.
  3. Blood Vessel and Blood Cells. Digital image. UNC Kidney Center. 14 May 2009 <http://www.unckidneycenter.org/images/Picture1_000.jpg>.
  4. Anti-GBM Disease. Digital image. UNC Kidney Center. 14 May 2009 <http://www.unckidneycenter.org/images/Picture2gbm.jpg>.
  5. Anti-GBM Disease in Lungs. Digital image. UNC Kidney Center. 14 May 2009 <
http://www.unckidneycenter.org/images/antigbmlung.jpg>.