Cogan’s Syndrome
First diagnoses in 1934 from Morgan and Baumgartner. (3)
eye.jpg
http://www.bpei.med.miami.edu/site/disease/disease_anatomy.asp

SIGNS AND SYMPTOMS:


The primary targets of Cogan's Syndrome are the eyes and the ears. This disease often begins with a short case of inflammatory eye disease, often interstitial keratitis, or inflammation of the cornea. This condition is caused by pain, tearing of the eye, and photophobia. Blurry vision is present. Few have permanent vision loss. (1)
After this condition passes, the patient will develop bilateral audiovestibular symptoms (hearing loss, ringing in the ears, balance problems, and vertigo). About half of the patients, lose all hearing capabilities. (1)
Other symptoms are present as well: (1,3)
8867.jpg
http://www.nlm.nih.gov/MEDLINEPLUS/ency/images/ency/fullsize/8867.jpg

  • Headache
  • Nausea
  • Vomiting
  • Weight loss
  • Fever
  • Joint Pain
  • Inflammatory Blood Vessels
Symptoms can fluctuate in frequency, but last throughout life. (3)


TESTING:


  • The primary test for Cogan’s syndrome is a slit-lamp examination. (1)
  • Recent work suggests an MRI scan of the ear can also diagnose. (2)
slit_lamp.jpg
http://www.nlm.nih.gov/MEDLINEPLUS/ency/imagepages/1140.htm


TREATMENT:
ear-anatomy.jpg
http://www.uvm.edu/cmsi/luse/images/ear-anatomy.jpg


Steroids are given immediately to decrease inflammation. This will decrease the likelihood of permanent blindness or deafness. (1)
If blindness occurs, corneal transplants have been given to restore eyesight. (3)
If deafness occurs, cochlear transplants have been given to restore hearing. (3)
Other treatments include: (3)
  • nonsteroidal anti-inflammatory drugs
  • oral antibiotics, such as tetracycline
Fatality occurs for 10% of patients. (3)


POPULATION AFFECTED:


  • People under the age of 40 are most likely to be diagnosed. (1)
  • It frequents people who have recently had an influenza infection or, in some, a Chlamydia infection. (1)
  • There is no preference due to gender. (4)
  • Those of Caucasian decent have greater risk. (1)


A TESTIMONY FROM A PATIENT:


http://www.american-hearing.org/disorders/autoimmune/coganpatient.html (1)


REFERENCES:


1: http://www.american-hearing.org/disorders/autoimmune/cogans_syndrome.html
2: http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Cogan%20Reese%20Syndrome
3: http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/35151.html

4: http://autoimmunedisease.suite101.com/article.cfm/cogans_syndrome